Palmatine es uno de los cuatro principales alcaloides de la protoberberina (junto con Berberine) y se encuentra comúnmente en plantas que confieren berberina, como Berberis Aristata y Tinospora cordifolia .

Nuestro análisis basado en evidencia características 4 referencias únicas a artículos científicos.

Análisis de investigación por y verificado por Equipo de investigación de Última actualización el 14 de junio de 2018.

Investigación científica

1Sources and pharmacology

Palmatine, along with Berberine and a few others, are compounds known as 'Protoberberine alkaloids' found in various plant species.


Palmatine has been shown to enhance the efficacy of Nerve Growth Factor (NGF) in neurons, by increasing the output of neurite from PC12 neurons exposed to an NGF stimuli.[1] These effects were also seen with Berberine and coptisine, with berberine being more effective than coptisine being more effective than palmatine. Protoberberine compounds also suppress catecholamine synthesis in neurons[2][3] with palmatine having a lower IC50 value. These suppressive effects are more potent with palmatine, and at least in regards to dopamine are not seen with coptisine.[4] These effects were seen through direction inhibition of the tyrosine hydroxylase enzyme.

Scientific Support & Reference Citations


  1. Shigeta K, et al. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids. Biosci Biotechnol Biochem. (2002)
  2. Lee MK, Kim HS. Inhibitory effects of protoberberine alkaloids from the roots of Coptis japonica on catecholamine biosynthesis in PC12 cells. Planta Med. (1996)
  3. Hsieh MT, et al. Effects of palmatine on motor activity and the concentration of central monoamines and its metabolites in rats. Jpn J Pharmacol. (1993)
  4. Shin JS, et al. Inhibition of dopamine biosynthesis by protoberberine alkaloids in PC12 cells. Neurochem Res. (2000)

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"Palmatine." 10 Aug 2013. Web. 4 Sep 2018.